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Titanium dioxide as used in sunscreens is commonly modified with other ingredients to ensure efficacy and stability. Examples of what are known as surface modifier ingredients used for titanium dioxide include stearic acid, isostearic acid, polyhydroxystearic acid, and dimethicone/methicone copolymer.
In 2021, the EFSA published a new opinion, stating that while titanium dioxide is not considered a concern for reproduction, development, or immunotoxicity, there is a lack of data to fully exclude a potential genotoxic effect. As a result, the European Union decided to ban its use as a food additive from May 2022, highlighting the importance of continuous monitoring and updating of safety assessments.
