china lithopone powder factory

In the world of industrial processing and manufacturing, the term 1250 mesh holds significant importance, particularly in the field of powder and particle size reduction. This refers to a screen or sieve with a very fine aperture, capable of separating particles down to an incredibly minute level. The demand for 1250 mesh products is driven by various industries such as pharmaceuticals, cosmetics, food processing, and mineral refining, among others, where ultra-fine particle sizes are essential for optimal performance.

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For research published in 2022 study in the journal Food and Chemical Toxicology, scientists examined “the genotoxicity and the intracellular reactive oxygen species induction by physiologically relevant concentrations of three different TiO2 nanomaterials in Caco-2 and HT29-MTX-E12 intestinal cells, while considering the potential influence of the digestion process in the NMs’ physiochemical characteristics.” They found a “DNA-damaging effect dependent on the nanomaterial,” along with the micronucleus assay suggesting “effects on chromosomal integrity, an indicator of cancer risk, in the HT29-MTX-E12 cells, for all the tested TiO2 nanomaterials.” Researchers concluded that the results showcase “evidence of concern” regarding titanium dioxide used as a food additive.

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While IARC listed titanium dioxide as “possibly carcinogenic to humans,” they also add that “there is inadequate evidence in humans for the carcinogenicity of titanium dioxide.” Of the four human studies that they reviewed, only one showed a potential risk for occupational workers inhaling titanium dioxide particles and lung cancer, while the other three showed no risk for cancer at all. And it’s key to note that IARC did not assess the effects of titanium dioxide found in foods.

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Lithopone was developed in the 1870s as a substitute for lead carbonate (lead white), to overcome its drawbacks of toxicity and poor weathering resistance. Within a few years, titanium dioxide displaced lithopone to become the white pigment (PW6) par excellence in the industry and the world’s best-selling inorganic pigment. However, titanium is a product whose price is subject to large price variations due to product availability. These price increases affect the competitiveness of finished products, and so the search for an alternative to titanium dioxide has generated a variety of possibilities to optimise its use. 

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