Made Safe only allows titanium dioxide as part of sunscreen solutions and diaper creams; all titanium dioxide must be non-nanoparticle. Made Safe does not allow titanium dioxide in any other personal care or household products.

In 2022, a year after the EFSA recommended against the use of E171, the Food Standards Australia New Zealand (FSANZ) conducted its own reassessment of titanium dioxide as a food additive. The agency concluded that titanium dioxide was indeed safe to use as a food additive. The United Kingdom and Canada came to similar conclusions.

The FDA has issued guidance clarifying the safe use of titanium dioxide pigment as a food colorant and has stated that titanium dioxide may be safely used in cosmetics, including those intended for use around the eye. FDA also regulates the safety and effectiveness of sunscreen active ingredients, including nanoscale titanium dioxide.