EFSA’s scientific advice will be used by risk managers (the European Commission, Member States) to inform any decisions they take on possible regulatory actions.

Lithopone, a chemical compound with a rich history, emerges as a vital substance in various industries. Comprising barium sulfate and zinc sulfide, this compound boasts unique properties that make it a popular choice in applications such as paints, inks, and plastics. Recognized for its exceptional opacity and brightness, lithopone significantly enhances the covering power of materials in which it is incorporated. Its inert nature and resistance to atmospheric influences contribute to its longevity in diverse formulations. As a white pigment, lithopone plays a pivotal role in achieving vibrant and enduring colors across a spectrum of products, marking it as a cornerstone in the realm of chemical compounds.

Scientists analyzed research that examined how titanium dioxide nanoparticles interact with the brain for a 2015 review published in Nanoscale Research Letters. The researchers wrote: “Once the TiO2 NPs are translocated into the central nervous system through [certain] pathways, they may accumulate in the brain regions. For their slow elimination rates, those NPs could remain in the brain zones for a long period, and the Ti contents would gradually increase with repeated exposure.” After reviewing dozens of studies, the scientists concluded: “Long-term or chronic exposure to TiO2 nanoparticles could potentially lead to the gradually increased Ti contents in the brain, which may eventually induce impairments on the neurons and glial cells and lead to CNS dysfunction as a consequence.”

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