Lithopone is chemically inert and practically insoluble in acids, alkalis and solvents. The optimized particle-size distribution of Lithopone attained by means of co-precipitation and calcining permit the achievement of a high apparent density, which imparts to Lithopone its low resin requirement and its excellent rheological behaviour.

Lithopone 30% is a perfect alternative to titanium dioxide in all natural and synthetic pigmented elastomers, as it is non-abrasive and extremely acid resistant. 

What does titanium dioxide do? 

Other research suggests that E171 could cause harm; however, those research processes did not consider how people are typically exposed to E171. Research that adds E171 to drinking water, utilizes direct injections, or gives research animals E171 through a feeding apparatus is not replicating typical human exposure. 

When asked about the recent Skittles lawsuit, the FDA said the agency does not comment on pending litigation.

The effects of TiO₂ NPs in plants