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A  2023 study published in the journal Environmental Research, scientists examined the effect of titanium dioxide nanoparticles on important gut bacteria in mice. Their results showed “the growth inhibitory effects could be associated with cell membrane damage caused by titanium dioxide nanoparticles to the bacterial strains. Metabolomics analysis showed that TiO2 NPs caused alterations in multiple metabolic pathways of gut bacteria, such as tryptophan and arginine metabolism, which were demonstrated to play crucial roles in regulating gut and host health.” The researchers also found that four different neuroprotective metabolites “were significantly reduced” in urine and in vitro bacteria and vivo urine samples. The researchers concluded: “Increasing evidence implies that the gut microbiome plays a profound role in regulating host metabolism. Our results illustrated that TiO2 NPs hindered the growth of four beneficial gut bacterial strains.”

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In addition to its production capabilities, the China Titanium Dioxide Plant is also dedicated to sustainability and environmental protection
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china titanium dioxide plant. The plant has implemented eco-friendly practices to minimize its impact on the environment, such as using renewable energy sources and reducing waste production. This commitment to sustainability has not only benefited the local community but has also enhanced the plant's reputation as a responsible corporate citizen.

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It should also be considered that due to the low pH in the stomach, the increased dissolution of the TiO2 particles may increase its bioavailability and may facilitate the entry of titanium ions into the blood circulation. Despite the relatively large consumption of TiO2 as a food additive, no studies on the effect of pH on its absorption and bioavailability have been found in the literature. This can be attributed to a general belief that TiO2is completely insoluble. However, this is not completely true, as TiO2 particles show a certain degree of solubility.

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