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Second, the present invention provides a large-scale industrial production process with low production cost, high efficiency, energy saving, and stable product quality with an annual production capacity of several hundred thousand tons. Selective leaching of zinc by ammonia method, combined with ammonium persulfate iron removal, vulcanization method and zinc powder replacement method to remove heavy metal elements such as nickel, copper, lead, cadmium and arsenic, and metathesis reaction to obtain nZnS-B a S0 4 crystal filter cake. The nano-Lide powder product is obtained by directly drying and pulverizing without high-temperature calcination. The resulting product is of good quality and industrially operable.

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In a 2017 study published in Scientific Reports, researchers exposed rats to human-relevant levels of E171 to examine the effects of intestinal inflammation and carcinogenesis. They saw that “a 100-day E171 treatment promoted colon microinflammation and initiated preneoplastic lesions while also fostering the growth of aberrant crypt foci in a chemically induced carcinogenesis model.” They continued: “Stimulation of immune cells isolated from Peyer’s Patches [which are clusters of lymphoid follicles found in the intestine] showed a decrease in Thelper (Th)-1 IFN-γ secretion, while splenic Th1/Th17 inflammatory responses sharply increased,” researchers wrote. “A 100-day titanium dioxide treatment promoted colon microinflammation and initiated preneoplastic lesions.” The scientists concluded: “These data should be considered for risk assessments of the susceptibility to Th17-driven autoimmune diseases and to colorectal cancer in humans exposed to TiO2 from dietary sources.”

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