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In conclusion, Sachtleben's TIO2 brand stands as a testament to the company's pioneering spirit and unyielding commitment to quality. As a leader in titanium dioxide production, they continue to push boundaries, seeking innovative solutions that contribute to both the advancement of their field and the broader industrial applications of TiO2. For those seeking a trusted partner in TiO2 pigments, Sachtleben remains an unrivaled choice, synonymous with excellence and reliability in the global marketplace.

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Additionally, the committee noted that the available data did not provide convincing evidence of genotoxicity for titanium dioxide as a food additive, but recognized the limitations in current methodologies with respect to the testing of poorly soluble particulate materials. Although there were uncertainties in the genotoxicity data, the experts took into account the fact that the additive was not carcinogenic in adequately conducted two-year studies in mice and rats at doses of up to 7,500 mg/kg BW per day for mice, and 2,500 mg/kg BW per day for rats, the highest doses tested. There was also no evidence of reproductive or developmental toxicity in studies in rats at doses up to 1,000 mg/kg BW per day, the highest doses tested.  

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