In its 2016 opinion, the ANS Panel recommended new studies be carried out to fill the gaps on possible effects on the reproductive system, which could enable them to set an Acceptable Daily Intake (ADI ). Uncertainty around the characterisation of the material used as the food additive (E 171) was also highlighted, in particular with respect to particle size and particle size distribution of titanium dioxide used as E 171.   

Despite a bullish trends ruling the market for the bulk of the period, the North American market had mixed sentiments in the fourth quarter of 2021. This was mostly due to the adequate pushback from the supply-demand imbalance, which was further compounded by rising natural gas prices, which had taken a proper toll on the future production of numerous minerals, including titanium dioxide. An increase in COVID instances had prompted concerns in ore feedstock. As a result, during the fourth quarter of 2021, the FD UGSC (USA) quarterly average negotiations for the chemical CP Rutile Grade were finalised at USD 4434 per tonne.