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TiO2 NPs appeared to be more toxic to nematode Caenorhabditis elegans than submicron-sized TiO2.  At a concentration of 1 mg/l, 7 nm particles affected its fertility and survival rate and were more toxic than 20 nm anatase particles. Similarly, Hu et al. showed that rutile particles (10–20 nm), at concentrations above 1 g/kg soil, can be bio-accumulated in earthworms, where they induce oxidative stress, inhibit the activity of cellulase and induce DNA and mitochondrial damage.

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In conclusion, lithopone is a valuable pigment that offers superior covering power, brightness, and lightfastness in various applications. Its versatility makes it a popular choice in industries such as paint, rubber, plastic, ceramics, and cosmetics. Quotes from suppliers emphasize the importance of lithopone as a key ingredient in different formulations, highlighting its quality and performance. As the demand for high-quality pigments continues to grow, lithopone remains a top choice for manufacturers seeking to enhance the visual appeal and durability of their products.

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