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The evidence also suggests that the toxicity of TiO2 particles may be reduced when eaten as part of the diet. This is because proteins and other molecules in a person's diet can bind to the TiO2 particles. This binding alters the physical and chemical properties of the particles, which influences how they interact with cells, tissues and organs.
3. Solubility: insoluble in water.
The mineral appears to have low skin penetration, but it is a greater concern when inhaled frequently over time.