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The titanium dioxide industry is a crucial sector in the global chemical market, with a wide range of applications in various industries such as paints, plastics, paper, and textiles. Titanium dioxide, also known as TiO2, is a white pigment that is widely used for its high refractive index and excellent stability. The demand for titanium dioxide has been steadily increasing over the years, driven by the growing construction and automotive industries.

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For research published in Archives of Toxicology in 2020, scientists fed one group of mice a solution containing titanium dioxide for one month, and compared it to those that did not receive the additive. They found “the richness and evenness of gut microbiota were remarkably decreased and the gut microbial community compositions were significantly changed” in the titanium dioxide group when compared with the control group. The tests also revealed that the titanium dioxide exposure could cause locomotor dysfunction, or mobility issues “by elevating the excitement of enteric neurons, which might spread to the brain via gut-brain communication by vagal pathway.” The researchers concluded: “These findings provide valuable insights into the novel mechanism of TiO2NP-induced neurotoxicity. Understanding the microbiota-gut-brain axis will provide the foundation for potential therapeutic or prevention approaches against TiO2NP-induced gut and brain-related disorders.”

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When it comes to sourcing titanium dioxide, it is essential to understand the various processes involved in its production. The two primary production methods are the sulfate process and the chloride process. The sulfate process tends to be more cost-effective in certain contexts, but it also generates a substantial amount of waste, putting pressure on manufacturers to invest in waste treatment technologies. On the other hand, the chloride process is known for its superior quality and lower environmental impact, albeit at a higher production cost.


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