The report also provides detailed information related to the lithopone manufacturing process flow and various unit operations involved in a manufacturing plant. Furthermore, information related to mass balance and raw material requirements has also been provided in the report with a list of necessary quality assurance criteria and technical tests.

In general, nanoparticles have been shown to accumulate in the body, particularly in organs in the gastrointestinal tract, along with the liver, spleen, and capillaries of the lungs.

Pigment grade titanium dioxide is produced at a much larger particle size than nano grade. It is used as a colourant to whiten and brighten product formulations. Nano grade titanium dioxide is manufactured into very fine (nano) particles and is transparent and colourless. It is commonly used in sunscreens to provide effective protection from potentially harmful UV rays.

In terms of manufacturers, there are many companies that produce calcium carbonate and titanium dioxide. Some of the top manufacturers of calcium carbonate include Omya, Imerys, and Minerals Technologies. These companies have large mining operations and production facilities in regions where calcium carbonate is abundant.