We've measured many different immunological markers, both in the mucosa of the intestine and the lymphoid organs part of the intestine and we didn't see any inflammation there or changes in white blood cell number, Kaminski said. They also looked at the spleen where titanium dioxide was taken up into the bloodstream. You would expect [titanium dioxide] would be filtered out in the spleen and maybe induce inflammation there, but we did not see that, Kaminski added.
When E171 isn’t combined with other ingredients and administered in water, some studies suggest that under these artificial conditions, E171 may be processed differently in the body resulting in some biological changes in experimental animals that are poorly understood.
