5. Regulatory compliance The MSDS should also include information on regulatory requirements for the safe handling and use of lithopone, including any permits or certifications that may be necessary.

FDA guidelines:Americans are eating too much salt. So the FDA wants food manufacturers to cut back on sodium.  

References

R-5566:

It adds a bright white color to coffee creamers, baked goods, chewing gums, hard-shell candies, puddings, frostings, dressings, and sauces. But the nanoparticles found in “food-grade” titanium dioxide may accumulate in the body and cause DNA damage—which is one way chemicals cause cancer and other health problems.