A 2022 review on past studies of titanium dioxide and rat lung cancer, for instance, said the original study was under extreme conditions and its effects were not replicated in other animal species. Additionally, the review concluded that the few studies which did directly focus on titanium dioxide's impact on humans did not end up showing any increased cancer risk.

For his part, Kaminski argues most of the studies have been in animals, and any effects found were minuscule. He and his team also contested some of the findings in a 2019 study that found no evidence of increased inflammation or changes in the GI tract.

The evidence also suggests that the toxicity of TiO₂ particles may be reduced when eaten as part of the diet. This is because proteins and other molecules in a person's diet can bind to the TiO₂ particles. This binding alters the physical and chemical properties of the particles, which influences how they interact with cells, tissues and organs.

The properties of lithopone are very suitable for use in the production of coatings. Because the ingredients of lithopone are zinc sulfide and barium sulfate, and the more zinc sulfide content, the stronger its covering power. This indicates a paint product with strong white covering power. It is different from water in that it reacts with acid but does not react with alkali. It has a wide range of uses. Because its structural properties are similar to titanium dioxide and its price is relatively cheap, it can also be used as a substitute for some titanium dioxide. Lithopone can be used for coloring paints, inks, pigments, rubber, paper, leather, enamel, etc.

This route affords a product that is 29.4 wt % ZnS and 70.6 wt % BaSO₄. Variations exist, for example, more ZnS-rich materials are produced when zinc chloride is added to the mixture of zinc sulfate and barium sulfide.^[1]

According to a 2011 study published in Radiology and Oncology, titanium dioxide may lead to some adverse effects in the body, including oxidative stress, inflammation, and changes in cell signaling pathways. Additionally, pure titanium dioxide can be notably harmful when inhaled.

Titanium dioxide has similar uses in non-food products. It is used in sunscreen as effective protection against UVA/UVB rays from the sun, which creates a physical barrier between the sun’s rays and the skin. It’s also used to whiten paint, paper, plastic, ink, rubber, and cosmetics.

Lithopone is used in water-based paints because of its excellent alkali resistance. It is also used as a whitener and reinforcing agent for rubber and as a filler and whitener for paper.

Promotion of noncancerous tumors

The global market for titanium dioxide is highly competitive, with manufacturers from around the world vying for market share. In order to stay competitive, manufacturers must continuously innovate and adapt to changing market trends. This may include expanding into new markets, developing new products, or forming strategic partnerships with other companies.

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It should also be considered that due to the low pH in the stomach, the increased dissolution of the TiO₂ particles may increase its bioavailability and may facilitate the entry of titanium ions into the blood circulation. Despite the relatively large consumption of TiO₂ as a food additive, no studies on the effect of pH on its absorption and bioavailability have been found in the literature. This can be attributed to a general belief that TiO₂is completely insoluble. However, this is not completely true, as TiO₂ particles show a certain degree of solubility.

Some consumer advocacy groups and health agencies — particularly, those at the Environmental Working Group — have been pushing federal officers at the Food and Drug Administration (FDA) to reconsider their existing rules on the additive, which is commonly found in processed snacks and sweets.

Because of health risks, France banned titanium dioxide as a food additive in 2020. Two years later the European Union also banned titanium dioxide as a food additive. 

Assessment of biocompatibility in eukaryotic cells

Panzhihua Dongfang TiO2 manufacturer has 28 patents related to titanium dioxide production by sulfuric acid method, 3 research results, and 5 registered trademarks. Excellent quality, excellent covering power, excellent system dispersion, good whiteness, high brightness, and low oil absorption. The company’s products are exported to more than 40 countries and regions in the world, and the export ratio is nearly 40%. It is the second largest exporter in Panzhihua City after Panzhihua Iron and Steel. Top 50, Sichuan Enterprise Technology Center, Panzhihua Municipal Government “Advanced Foreign Trade Export Enterprise” and other titles