Lithopone is a white pigment (PW5) co-precipitated from solutions of zinc and barium salts according to the following reaction: 

The FDA has not updated its general guidance on safety assessments since 2007. Within that time, there has been a significant increase in research on the confluence of toxicology, nanotechnology and human health. The EU updates its guidance regularly with new science available to offer proper safety assessments, with its most recent update published in 2021.

Lithopone B301, Lithopone B311 powder’s 2 main components: