In June 2022, Health Canada weighed in on the debate, releasing a report on the safety of titanium dioxide. Their expert panel reviewed toxicity studies, including ones involving genetic damage. The expert panel found that previous studies used different forms and properties of titanium dioxide and deliberately broke the material into smaller particles than what you would normally see in food.

Until relevant toxicological and human exposure data that would enable reliable risk assessment are obtained, TiO₂ nanoparticles should be used with great care.