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In the world of pigments, titanium dioxide stands tall as a favorite material for its ability to provide brilliant whiteness and exceptional opacity. Its refractive index is high, making it ideal for achieving that pure, lustrous look in paints and coatings. But its capabilities don’t end there; titanium dioxide is also prized for its stability and resistance to discoloration, ensuring longevity in artistic creations and protective layers.

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In a study published in the journal Food and Chemical Toxicology in 2016, researchers investigated whether titanium dioxide exposure led to an increase in colorectal tumor creation in mice by using a colitis associated cancer model. By measuring tumor progression markers, the researchers found that mice given titanium dioxide experienced enhanced tumor formation in the distal colon.  There was also a decrease of cells that act as a protective barrier in the colon. The researchers wrote: “These results suggest that E171 could worsen pre-existent intestinal diseases.”

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