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In short, no, research demonstrates that E171 is safe when consumed in normal situations.

Moreover, how we're exposed to an ingredient matters significantly in terms of our health and potential toxicity.   

Research shows that inhaling titanium dioxide particles in significant quantities over time can cause adverse health outcomes. Unless you work in an industrial setting, inhaling substantial amounts of titanium dioxide is highly unlikely. 

Research supports that applying titanium dioxide to the skin in the form of sunscreens, makeup, and other topical products does not pose a health risk. 

Overwhelmingly, research that's relevant to human exposure shows us that E171 is safe when ingested normally through foods and drugs (1,2).

Again, other research suggests that E171 could cause harm; however, those research processes did not design their studies to model how people are exposed to E171. Research that adds E171 to drinking water, utilizes direct injections, or gives research animals E171 through a feeding apparatus is not replicating typical human exposure, which occurs through food and medicine consumption.

Read more in-depth about the titanium dioxide risk at go.msu.edu/8Dp5. 

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Another approach utilizes titrimetry, where a standard solution of a titrant, such as lead perchlorate or barium perchlorate, is used to react with the sulfate ions. The endpoint of the titration is determined either by a color change indicator or more sophisticated instrumentation like a potentiometric titrator The endpoint of the titration is determined either by a color change indicator or more sophisticated instrumentation like a potentiometric titrator The endpoint of the titration is determined either by a color change indicator or more sophisticated instrumentation like a potentiometric titrator The endpoint of the titration is determined either by a color change indicator or more sophisticated instrumentation like a potentiometric titratordetermination of sulphate as tio2. The volume of titrant used corresponds to the concentration of sulfate in the sample. Again, a stoichiometric calculation converts this to TiO2 content.

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