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In a study published in the journal Food and Chemical Toxicology in 2016, researchers investigated whether titanium dioxide exposure led to an increase in colorectal tumor creation in mice by using a colitis associated cancer model. By measuring tumor progression markers, the researchers found that mice given titanium dioxide experienced enhanced tumor formation in the distal colon.  There was also a decrease of cells that act as a protective barrier in the colon. The researchers wrote: “These results suggest that E171 could worsen pre-existent intestinal diseases.”

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The Chinese titanium dioxide industry has experienced exponential growth over the past decades, accounting for a substantial portion of the global output. This boom is driven by the country's vast resources of ilmenite, a primary source of titanium, and the demand from various sectors. However, the manufacturing process of TiO2 involves large amounts of water, which can lead to potential water pollution if not managed properly.

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