In the context of titanium dioxide determination, the process generally begins with the sample preparation, where a known mass of the sample containing TiO2 is dissolved or digested appropriately. The subsequent steps involve adding a precipitating agent, such as ammonium sulfate or sulfuric acid, to the prepared solution, which facilitates the formation of a titanium precipitate. This precipitate is often titanium hydroxide, which is not only insoluble but can be easily filtered out from the liquid phase.

Health Canada's Food Directorate recently completed a “state of the science” report on titanium dioxide (TiO₂) as a food additive. Food-grade TiO₂ is a white powder made up of small particles that has been permitted in Canada and internationally for many years as a food additive to whiten or brighten foods. Food-grade TiO₂ has long been considered safe in Canada and in other countries when eaten as part of the diet.