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Drobne et al. used the terrestrial arthropod Porcellio scaber as a test organism for determining the cytotoxic effect of TiO2 NPs (anatase). The animals were exposed to TiO2 NPs of two different sizes (25 nm and 75 nm) in the concentration range 10–1000 μg TiO2/g dry food for 3 to 14 days. No adverse effects, such as mortality, body weight changes or reduced feeding, were observed. In fact, quite the opposite, an enhanced feeding rate, food absorption efficiency and increase in catalase activity were observed. The intensity of these responses appeared to be time- but not dose-dependent. It should also be noted that the concentrations tested in this study were much higher than the predicted concentration (4.8 μg/g soil) at high emission scenario of nano-sized TiO2. Using the same test organism another group showed that exposure to TiO2 NPs induced destabilization of cell membrane in the epithelium of digestive glands isolated from exposed animals. They also showed that this effect can be observed after just 30 minutes of exposure.

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Overall, the use of TiO2 in factory settings plays a crucial role in enhancing the quality, performance, and appearance of a wide range of products. Its unique properties make it an invaluable ingredient in various industrial processes, allowing manufacturers to create high-quality, durable, and visually appealing finishes. As technology continues to advance, the demand for TiO2 is expected to grow, further solidifying its importance in the manufacturing industry.


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