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The global lithopone pigment market is driven by the growth of end-use industries, particularly construction and automotive, where coatings and plastics play a significant role. Manufacturers are constantly innovating to improve the quality of lithopone pigments, focusing on enhancing their whiteness, opacity, and weather resistance. Environmental concerns have also led to the development of eco-friendly production methods, reducing waste and minimizing the environmental footprint.

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The gastrointestinal tract is a complex barrier/exchange system, and is the most important route by which macromolecules can enter the body. The main absorption takes place through villi and microvilli of the epithelium of the small and large intestines, which have an overall surface of about 200 m2. Already in 1922, it was recognized by Kumagai, that particles can translocate from the lumen of the intestinal tract via aggregation of intestinal lymphatic tissue (Peyer’s patch, containing M-cells (phagocytic enterocytes)). Uptake can also occur via the normal intestinal enterocytes. Solid particles, once in the sub-mucosal tissue, are able to enter both the lymphatic and blood circulation.

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