In vitro, in the hemocytes of the marine mussel Mytilus hemocytes, suspension of TiO2 NPs (Degussa P25, 10 μg/ml) stimulated immune and inflammatory responses, such as lysozyme release, oxidative burst and nitric oxide production. Vevers and Jha demonstrated the intrinsic genotoxic and cytotoxic potential of TiO2 NPs on a fish-cell line derived from rainbow-trout gonadal tissue (RTG-2 cells) after 24 h of exposure to 50 μg/ml. Reeves et al. demonstrated a significant increase in the level of oxidative DNA damage in goldfish cells, and suggested that damage could not repaired by DNA repair mechanisms. Another suggestion from the mentioned study was that hydroxyl radicals are generated also in the absence of UV light. It has been shown that fish cells are generally more susceptible to toxic/oxidative injury than mammalian cells.
By reducing processed foods in your diet, you can reduce the likelihood of not only eating titanium dioxide but eating other chemicals of concern, Faber said, noting that consumers can also call their elected representatives urging them to support increased food safety legislation and take action with organization alliances like Toxic Free Food FDA. America, once again, is falling behind the rest of the world when it comes to chemical safety.
Other research suggests that E171 could cause harm; however, those research processes did not consider how people are typically exposed to E171. Research that adds E171 to drinking water, utilizes direct injections, or gives research animals E171 through a feeding apparatus is not replicating typical human exposure.