The vitaminB2@TiO₂NPs were obtained at room temperature, by a method developed after trying several ratios of reactants. Briefly, 0.02 g of P25TiO₂NPs were dispersed in 1 mL of ultra-pure water and stirred in a Vortex. Next, 200 μl of vitamin B2 dissolved in ultra-pure water (5.3 × 10⁻³ M) were added to 200 μL of P25TiO2NPs and the mixture was ultrasonicated for 1 hour to achieve a deep-yellow homogeneous suspension. The pellet obtained after centrifuging the suspension for 10 min at 4500 rpm was resuspended in ultrapure water, centrifuged again, and then lyophilized.

Should I be worried about the use of titanium dioxide in my toothpaste?

It is suitable as an alternative to titanium dioxide when higher acid resistance is required, such as in adhesive joints and sealants. 

We apply titanium dioxide to our skin through sunscreens, makeup, lip balms, nail polish, and other cosmetic products. 

When E171 isn’t combined with other ingredients and administered in water, some studies suggest that under these artificial conditions, E171 may be processed differently in the body resulting in some biological changes in experimental animals that are poorly understood.