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Australian researchers examined how titanium dioxide as a food additive affected gut microbiota in mice by orally administering it in drinking water. The study, published in the journal Frontiers in Nutrition in 2019, found the treatment could “alter the release of bacterial metabolites in vivo and affect the spatial distribution of commensal bacteria in vitro by promoting biofilm formation. We also found reduced expression of the colonic mucin 2 gene, a key component of the intestinal mucus layer, and increased expression of the beta defensin gene, indicating that titanium dioxide significantly impacts gut homeostasis.” The changes were then linked to colonic inflammation, along with a higher expression of inflammatory cytokines, which are signal proteins that help with regulation. The researchers concluded that titanium dioxide “impairs gut homeostasis which may in turn prime the host for disease development.”

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In the paper industry, titanium dioxide is used as a coating to improve the opacity and printability of paper products
titanium
titanium dioxide used for white pigments. The pigment helps to create a bright white surface that enhances the visual appeal of printed materials, making them more attractive and professional-looking. TiO2 is also used in the production of inkjet papers and photo printing papers to achieve high-quality images with sharp colors and fine details.

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