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Inductively coupled plasma-optical emission spectrometry (ICP-OES) is another popular method for determining barium in TiO2. This technique uses an inductively coupled plasma to ionize the sample and then measures the intensity of light emitted by the resulting ions. ICP-OES offers high sensitivity and wide dynamic range, allowing for the detection of trace amounts of barium. It also requires specialized equipment, but its automation capabilities can reduce costs and improve efficiency.

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Recently, Yanagisawa et al. reported that the transdermal exposure (mimicking skin-barrier dysfunction or defect) of NC/Nga mice to TiO2 NPs (15, 50, or 100 nm), in combination with allergen, aggravated atopic dermatitis-like lesions through a T-helper type 2 (Th2) dominant immune response. The study also indicated that TiO2 NPs can play a role in the initiation and/or progression of skin diseases, since histamine was released, even in the absence of allergen.

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