In a 2017 study published in Scientific Reports, researchers exposed rats to human-relevant levels of E171 to examine the effects of intestinal inflammation and carcinogenesis. They saw that “a 100-day E171 treatment promoted colon microinflammation and initiated preneoplastic lesions while also fostering the growth of aberrant crypt foci in a chemically induced carcinogenesis model.” They continued: “Stimulation of immune cells isolated from Peyer’s Patches [which are clusters of lymphoid follicles found in the intestine] showed a decrease in Thelper (Th)-1 IFN-γ secretion, while splenic Th1/Th17 inflammatory responses sharply increased,” researchers wrote. “A 100-day titanium dioxide treatment promoted colon microinflammation and initiated preneoplastic lesions.” The scientists concluded: “These data should be considered for risk assessments of the susceptibility to Th17-driven autoimmune diseases and to colorectal cancer in humans exposed to TiO2 from dietary sources.”
Another crucial property of TiO2 is that it can show photocatalytic activity under UV light. This makes it effective for environmental purification, for different kinds of protective coatings, sterilisation and anti-fogging surfaces, and even in cancer therapy.
Natural barite and anthracite containing more than 95% barium sulfate are mixed and fed at a ratio of 3:1 (mass). After being crushed to a diameter of less than 2cm, it enters the reduction furnace. The furnace temperature is controlled to be 1000-1200°C in the front section and 500-500 in the back section. 600°C, the reduction furnace rotates at a speed of 80 seconds per revolution, and the reaction conversion rate is 80% to 90%.