Titanium dioxide is the most widely used whitening pigment in the world and has been linked to adverse health effects, particularly genotoxicity and intestinal inflammation. It is applied as food coloring and a whitening agent to a wide variety of foods, including chewing gum, cakes, candies, breads and ice cream. 

Example of partial substitution of titanium dioxide with lithopone supplier 30% in a white masterbatch 

ROS were detected through the colorimetric assay employing the nitro-blue tetrazolium salt (NBT salt) by reading the absorbance of the reduced blue molecule.