A 2023 study published in the journal Particle and Fibre Toxicology set out to examine the impact of titanium dioxide nanoparticles in mice “on the course and prognosis of ulcerative colitis,” by creating an ulcerative colitis disease model. Researchers found that the titanium dioxide nanoparticles significantly increased the severity of colitis. They also “decreased the body weight, increased the disease activity index and colonic mucosa damage index scores, shortened the colonic length, increased the inflammatory infiltration in the colon.” Researchers concluded: “Oral intake of TiO2 nanoparticles could affect the course of acute colitis in exacerbating the development of ulcerative colitis, prolonging the ulcerative colitis course and inhibiting ulcerative colitis recovery.”

1. 296 to 1.357 g/cm3 is obtained. The reaction solution is subjected to pressure filtration through a plate frame to obtain a cake-like lithopone powder having a water content of not more than 45%. The mixture is calcined in a dry roaster to change the crystal form of the lithopone, and then acid-washed with sulfuric acid at a temperature of 80 °C. Finally, it is washed with water, reinforced with coloring agent, pressure filtration, drying and milling.