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In a study published in the journal Environmental Toxicology and Pharmacology in 2020, researchers examined the effects of food additives titanium dioxide and silica on the intestinal tract by grouping and feeding mice three different food-grade particles — micro-TiO2, nano-TiO2, and nano-SiO2.  With all three groups, researchers observed changes in the gut microbiota, particularly mucus-associated bacteria. Furthermore, all three groups experienced inflammatory damage to the intestine, but the nano-TiO2 displayed the most pronounced changes. The researchers wrote: “Our results suggest that the toxic effects on the intestine were due to reduced intestinal mucus barrier function and an increase in metabolite lipopolysaccharides which activated the expression of inflammatory factors downstream. In mice exposed to nano-TiO2, the intestinal PKC/TLR4/NF-κB signaling pathway was activated. These findings will raise awareness of toxicities associated with the use of food-grade TiO2 and SiO2.”

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In conclusion, China's role in the global TiO2 market is significant, particularly in the paints and inks sector. With its abundant resources, advanced manufacturing capabilities, and commitment to quality and sustainability, China will continue to be a major player in the TiO2 industry for years to come. By addressing environmental challenges and maintaining a focus on innovation, China can further strengthen its position as a leading producer and exporter of TiO2 in the global market.

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The lithopone factory in China plays a crucial role in the global pigment industry, providing high-quality products at competitive prices. While the industry faces challenges, the government's efforts to promote sustainable development and the increasing demand for eco-friendly products offer opportunities for growth. As the industry continues to evolve, it will be important for factories to adopt environmentally friendly practices and innovate to remain competitive in the global market.

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