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In 2017, French researchers from the Institut National de la Recherche Agronomique (INRAE) were among the first to examine the effects of E171 nanoparticles on the body. They fed rats a dose of 10mg of E171 per kilogram of body weight per day, which was similar to human exposure in food. The research, which was published in Scientific Reports, showed that E171 was able to traverse the intestinal barrier, pass into the bloodstream, and reach other areas of the body in rats. Researchers also found a link between immune system disorders and the absorption of titanium dioxide nanoparticles. 

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Metal detectors can not only detect a variety of metals at various depths depending on the size of the object, but some can even detect the differences between various metals. This differentiation is done by measuring the deflection of the magnetic field generated by the metal detector. Titanium is often used in medical implants, so patients with implants that contain titanium often have to make this known to airport security personnel in order to pass inspection.

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Modern lithopone factories are at the forefront of this revolution. They employ cutting-edge technology to reduce energy consumption and optimize production processes. Advanced filtration systems ensure that the end product is free from impurities, while closed-loop systems recycle water and other byproducts, significantly reducing the environmental footprint. Moreover, these facilities are increasingly powered by renewable energy sources, aligning manufacturing practices with sustainability goals.

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