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In the paint industry, titanium dioxide serves as a critical component due to its excellent hiding power and durability. It enhances the coverage of paints and protects substrates from UV damage, extending the lifespan of coatings. In plastics, it not only provides color but also improves the strength and stability of the final product. In paper manufacturing, titanium dioxide contributes to higher opacity and printability, resulting in superior graphic arts products.

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Moreover, TiO2 can also improve the mechanical properties of plastics. It increases the stiffness and strength of the material, making it more resistant to impact and deformation. This is particularly beneficial in applications where plastics are subjected to stress or pressure, such as automotive parts and construction materials. By incorporating TiO2 into their formulations, manufacturers can create stronger and more durable plastic products without sacrificing their lightweight nature.

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Recently, Yanagisawa et al. reported that the transdermal exposure (mimicking skin-barrier dysfunction or defect) of NC/Nga mice to TiO2 NPs (15, 50, or 100 nm), in combination with allergen, aggravated atopic dermatitis-like lesions through a T-helper type 2 (Th2) dominant immune response. The study also indicated that TiO2 NPs can play a role in the initiation and/or progression of skin diseases, since histamine was released, even in the absence of allergen.

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