In some studies, E171 was given to animals in drinking water without the stabilizers that keep E171 suspended in the liquid. Without stabilizers, E171 can settle and prevent the ingredient from combining with surrounding ingredients.

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3. Safety measures The MSDS should provide recommendations for safe handling, storage, and disposal of lithopone. This may include guidelines for personal protective equipment, proper ventilation, and spill response procedures.

Manufacturers get titanium dioxide from minerals called brookite, rutile, and anatase. It's processed into a powder and refined to meet strict safety guidelines.

From studies deemed relevant, the experts found that titanium dioxide as a food additive is poorly absorbed by the gastrointestinal tract of mice and rats, with no adverse effects observed in short-term studies in rodents receiving titanium dioxide in their diets. No observed adverse effect levels (NOAELs) of 15,000 milligrams per kilogram of bodyweight (mg/kg BW) per day and 5,000 mg/kg BW per day—the highest doses tested—were established for mice and rats, respectively.