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The titanium dioxide industry is a crucial sector in the global chemical market, with a wide range of applications in various industries such as paints, plastics, paper, and textiles. Titanium dioxide, also known as TiO2, is a white pigment that is widely used for its high refractive index and excellent stability. The demand for titanium dioxide has been steadily increasing over the years, driven by the growing construction and automotive industries.

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This article discusses the discovery of phosphorescent lithopone on watercolor drawings by American artist John La Farge dated between 1890 and 1905 and the history of lithopone in the pigment industry in the late 19th and early 20th centuries. Despite having many desirable qualities for use in white watercolor or oil paints, the development of lithopone as an artists’ pigment was hampered by its tendency to darken in sunlight. Its availability to, and adoption by, artists remain unclear, as colormen's trade catalogs were generally not explicit in describing white pigments as containing lithopone. Further, lithopone may be mistaken for lead white during visual examination and its short-lived phosphorescence can be easily missed by the uninformed observer. Phosphorescent lithopone has been documented on only one other work-to-date: a watercolor by Van Gogh. In addition to the history of lithopone's manufacture, the article details the mechanism for its phosphorescence and its identification aided by Raman spectroscopy and spectrofluorimetry.

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Anatase, known for its excellent photocatalytic activity, is primarily used in the production of advanced materials and environmental protection products. Its unique ability to break down pollutants under sunlight makes it an ideal choice for air purification and self-cleaning surfaces. On the other hand, Rutile, with its superior opacity and durability, is more commonly used in the coatings, plastics, and paper industries, providing a white pigment and UV protection.

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In addition to environmental sustainability, TiO2 technology manufacturers are also focused on improving the performance and quality of TiO2 products
tio2
tio2 technology manufacturers. By utilizing advanced technologies, such as nanotechnology and surface modification techniques, manufacturers are able to enhance the properties of TiO2, such as its UV resistance, dispersibility, and durability. These advancements allow TiO2 manufacturers to produce high-performance products that meet the diverse needs of their customers.

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In a 2020 study published in the Journal of Trace Elements in Medicine and Biology, researchers conducted an in vitro experiment to analyze the effects of TiO2 nanoparticles on a human neuroblastoma (SH-SY5Y) cell line. The scientists evaluated “reactive oxygen species (ROS) generation, apoptosis, cellular antioxidant response, endoplasmic reticulum stress and autophagy.” The results showed that exposure to the nanoparticles “induced ROS generation in a dose dependent manner, with values reaching up to 10 fold those of controls. Nrf2 nuclear localization and autophagy also increased in a dose dependent manner. Apoptosis increased by 4- to 10-fold compared to the control group, depending on the dose employed.” 

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