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The safety of food-grade titanium dioxide, or E171, lies in its ultrafine particle size. These particles are too small to be absorbed by the human body, passing through the digestive system without causing harm. Extensive research has been conducted to confirm this, with studies showing no evidence of genotoxicity or carcinogenicity. However, recent concerns about potential effects from nano-sized particles have led to ongoing evaluations However, recent concerns about potential effects from nano-sized particles have led to ongoing evaluations However, recent concerns about potential effects from nano-sized particles have led to ongoing evaluations However, recent concerns about potential effects from nano-sized particles have led to ongoing evaluationsfood safe titanium dioxide.

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The photocatalytic properties of titanium dioxide are particularly interesting. When exposed to ultraviolet radiation, TiO2 can catalyze reactions that decompose organic compounds, leading to its use in self-cleaning surfaces and air purification systems When exposed to ultraviolet radiation, TiO2 can catalyze reactions that decompose organic compounds, leading to its use in self-cleaning surfaces and air purification systems When exposed to ultraviolet radiation, TiO2 can catalyze reactions that decompose organic compounds, leading to its use in self-cleaning surfaces and air purification systems When exposed to ultraviolet radiation, TiO2 can catalyze reactions that decompose organic compounds, leading to its use in self-cleaning surfaces and air purification systemschemical titanium dioxide. This property is utilized in construction materials like concrete and glass, where the titanium dioxide helps to break down pollutants and reduce maintenance requirements.

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The vitaminC@P25TiO2NPs, on the other side, did not have any effect on cell protection against ROS. This might be due to the fact that vitamin C, a well-known scavenger of ROS, could behave as prooxidant and even promote ROS and lipid peroxidation [39]. It was recently described that at small concentrations of vitamin C, the prooxidant effects dominate; while in large concentrations the antioxidant ones predominate [40]. The effect also depends on the cell state and the interaction of vitamin C with light. In this case, ascorbic acid may act as an antenna to harvest visible light when conjugated to P25TiO2NPs. Indeed, it was previously found that this combination (in some ratios) could have an improved photocatalytic activity, possibly due to a red shift in its light absorbance [41]. Further studies on vitaminC@P25TiO2NPs were not conducted, because of the poor antioxidant capacity [42].

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