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China has emerged as a pivotal player in the global titanium dioxide industry, with its importers playing a crucial role in shaping the dynamics of this sector. Titanium dioxide, also known as TiO2, is a white pigment widely used in various applications such as paints, plastics, paper, and cosmetics. The country's growing demand for this versatile compound has led to an increase in import activities, making Chinese importers a vital link between domestic consumers and international producers.

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Recently, Yanagisawa et al. reported that the transdermal exposure (mimicking skin-barrier dysfunction or defect) of NC/Nga mice to TiO2 NPs (15, 50, or 100 nm), in combination with allergen, aggravated atopic dermatitis-like lesions through a T-helper type 2 (Th2) dominant immune response. The study also indicated that TiO2 NPs can play a role in the initiation and/or progression of skin diseases, since histamine was released, even in the absence of allergen.

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