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From studies deemed relevant, the experts found that titanium dioxide as a food additive is poorly absorbed by the gastrointestinal tract of mice and rats, with no adverse effects observed in short-term studies in rodents receiving titanium dioxide in their diets. No observed adverse effect levels (NOAELs) of 15,000 milligrams per kilogram of bodyweight (mg/kg BW) per day and 5,000 mg/kg BW per day—the highest doses tested—were established for mice and rats, respectively.

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In conclusion, the world of titanium dioxide manufacturers is vast and complex, with numerous players contributing to the global supply of this essential material. Companies like those mentioned above lead the way in producing high-quality TiO2 while continuously striving to improve their processes and products. Whether it's Hitox, Tio2, or any other brand or type of titanium dioxide, understanding the nuances of each manufacturer's offering is key to selecting the right product for specific industrial needs.

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