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Scientists analyzed research that examined how titanium dioxide nanoparticles interact with the brain for a 2015 review published in Nanoscale Research Letters. The researchers wrote: “Once the TiO2 NPs are translocated into the central nervous system through [certain] pathways, they may accumulate in the brain regions. For their slow elimination rates, those NPs could remain in the brain zones for a long period, and the Ti contents would gradually increase with repeated exposure.” After reviewing dozens of studies, the scientists concluded: “Long-term or chronic exposure to TiO2 nanoparticles could potentially lead to the gradually increased Ti contents in the brain, which may eventually induce impairments on the neurons and glial cells and lead to CNS dysfunction as a consequence.”

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Wegman’s puts titanium dioxide in its Original Macaroni and Cheese. Campbell’s Healthy Request Chunky Chicken Corn Chowder has it, as does Food Club’s Chunky New England Clam Chowder. Marzetti uses the color agent to brighten its Cream Cheese Fruit Dip. Dairy products usually don’t need titanium dioxide to look white, but Kroger has decided to add titanium dioxide to its Fat Free Half-and-Half. And titanium dioxide isn’t only in especially white or brightly colored foods: Little Debbie adds it to Fudge Rounds and many other products. According to the Food Scores database maintained by Environmental Working Group, more than 1,800 brand-name food products have titanium dioxide on their ingredients list. That said, it can still lurk as an unspecified “artificial color,” or labels might simply say “color added.”

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In conclusion, rutile titanium dioxide is a remarkable material with a wide range of applications in various industries. Its high refractive index, chemical stability, and photocatalytic activity make it an ideal choice for applications where these properties are crucial. With ongoing research and development, the potential uses of rutile TiO2 are likely to expand even further, leading to new and innovative applications in the future.

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In conclusion, the top 20 titanium dioxide manufacturers represent a cross-section of innovation, reliability, and commitment to quality. These companies are instrumental in driving the development of new products and applications while ensuring the consistent supply of this crucial material. As the demand for titanium dioxide continues to grow across various industries, these manufacturers will undoubtedly play a significant role in shaping the future of this versatile compound.

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