Hebei Caixin Material Technology Co., LTD., formerly established in 2005, is located in the core of Beijing-Tianjin-Hebei City cluster, close to Tianjin Port, the largest port in the north, with developed transportation and outstanding people. After the continuous efforts of Caiqing people, has accumulated assets for the company of nearly 200 million, nearly 1,000 employees, Caiqing technology has become the pigment titanium dioxide research and development, production, sales and import and export trade in one of the large company, we integrate industry resources, to provide personalized customized services for global customers. We adhere to the market-oriented, good faith as the principle, is committed to open up a diversified international market, for the world customers to provide quality products, efficient service, is our unremitting pursuit. We sincerely invite customers from all over the world to visit our company.

In some studies, E171 was given to animals in drinking water without the stabilizers that keep E171 suspended in the liquid. Without stabilizers, E171 can settle and prevent the ingredient from combining with surrounding ingredients.

Alterations in gut microbiota

Insolube matter in water

Other scientists, however, have called into question the experimental designs of such studies, citing inconsistent results specifically in studies used to test DNA damage.

Fig. 8. Selected images of skin stratus treated with P25TiO₂NPs 10% (left) and VitaminB2@P25TiO₂NPs 10% (right) under light, showing no penetration of the nanoparticles (white arrows) beyond the outer stratum corneum.

One of the primary advantages of lithopone is its excellent thermal stability. It performs well under high-temperature conditions, which is essential for paints that will be exposed to extreme weather. Lithopone’s resistance to UV radiation helps maintain the brightness and color integrity of paints, making it a preferred choice for outdoor applications. As a result, many suppliers are focusing on providing lithopone that meets the specific needs of manufacturers in the architectural, automotive, and industrial paint sectors.

According to data released by the China Coatings Industry Association, the total production of China's coatings industry has increased from 12.72 million tons in 2012 to 24.388 million tons in 2019, with a compound annual growth rate of 9.7%. Coatings, as an intermediate commodity, are closely related to downstream consumer markets such as the automotive industry, real estate, infrastructure, and home furnishings.

Analyst Insight

Titanium dioxide, or TiO2, sometimes referred to as E171, is an inorganic, solid substance used in a wide range of consumer goods including cosmetics, paint, plastic and food, according to the American Chemistry Council.

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Acknowledgements

In summary, the Food Directorate's position is that there is no conclusive scientific evidence that the food additive TiO₂ is a concern for human health. This is based on a review of the available scientific data relevant to food uses of TiO₂. However, we will continue to monitor the emerging science on the safety of TiO₂ as a food additive and may revisit our position if new scientific information becomes available.

A  2023 study published in the journal Environmental Research, scientists examined the effect of titanium dioxide nanoparticles on important gut bacteria in mice. Their results showed “the growth inhibitory effects could be associated with cell membrane damage caused by titanium dioxide nanoparticles to the bacterial strains. Metabolomics analysis showed that TiO2 NPs caused alterations in multiple metabolic pathways of gut bacteria, such as tryptophan and arginine metabolism, which were demonstrated to play crucial roles in regulating gut and host health.” The researchers also found that four different neuroprotective metabolites “were significantly reduced” in urine and in vitro bacteria and vivo urine samples. The researchers concluded: “Increasing evidence implies that the gut microbiome plays a profound role in regulating host metabolism. Our results illustrated that TiO2 NPs hindered the growth of four beneficial gut bacterial strains.”

On the other hand, Westerhoff said, there are hundreds of studies showing no adverse effects from the substance.