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In conclusion, China's role in the global titanium dioxide industry, identified by its CAS number 13463-67-7, is both influential and complex. While the country's abundant resources and manufacturing prowess have solidified its position as a major supplier, it faces the ongoing challenge of balancing economic growth with environmental sustainability. As the world shifts towards cleaner practices, China's journey in the titanium dioxide sector will continue to shape the industry's future direction.

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Recently, Yanagisawa et al. reported that the transdermal exposure (mimicking skin-barrier dysfunction or defect) of NC/Nga mice to TiO2 NPs (15, 50, or 100 nm), in combination with allergen, aggravated atopic dermatitis-like lesions through a T-helper type 2 (Th2) dominant immune response. The study also indicated that TiO2 NPs can play a role in the initiation and/or progression of skin diseases, since histamine was released, even in the absence of allergen.

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