tiona 595 titanium dioxide factories

In conclusion, anatase titanium dioxide is a safe and effective food-grade additive that provides a range of functional benefits to food products. Its stability, inertness, and lack of adverse effects make it an ideal choice for use in a wide variety of food applications. While there are still some unanswered questions about the safety of TiO2, the available evidence suggests that it is safe for use in food products at current levels of consumption.

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For research published in 2022 study in the journal Food and Chemical Toxicology, scientists examined “the genotoxicity and the intracellular reactive oxygen species induction by physiologically relevant concentrations of three different TiO2 nanomaterials in Caco-2 and HT29-MTX-E12 intestinal cells, while considering the potential influence of the digestion process in the NMs’ physiochemical characteristics.” They found a “DNA-damaging effect dependent on the nanomaterial,” along with the micronucleus assay suggesting “effects on chromosomal integrity, an indicator of cancer risk, in the HT29-MTX-E12 cells, for all the tested TiO2 nanomaterials.” Researchers concluded that the results showcase “evidence of concern” regarding titanium dioxide used as a food additive.

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