Titanium dioxide (TiO2) is a naturally occurring compound that is mined, refined and processed into a fine powder. It is known for its exceptional opacity, brightness and high refractive index, making it an ideal ingredient in paint formulations. When added to paint, titanium dioxide scatters and reflects light, creating vibrant, long-lasting colors. It is this unique property that makes titanium dioxide the most widely used white pigment in the coatings industry.

A number of our toothpastes do not contain titanium dioxide, including some of our Signal products (Signal Bio, Signal Nature Element, Signal White System, Signal Kids (Baby & Junior), Signal White Now Detox, Signal Anti-Cavity), Love Beauty and Planet and Schmidt’s Naturals.

In the meantime, some big manufacturers boosted their product pricing to better their margins, such as Venator, which increased its titanium dioxide prices by roughly 160 USD /MT for the third quarter of 2021 in the North America region. Overall, prices for Anatase grade in the United States hovered about 3485 USD /MT through the end of June.

The integrity of surface skin cells was evaluated with and without solar simulated irradiation. The integrity of the stratum corneum was significantly lower in individuals treated with P25TiO₂NPs under the light in comparison to the ones that received the functionalized nanoparticles. Cell membrane suffering is evident (Fig. 9), and it is in accordance with the ROS levels and macromolecule oxidation found in vitro for the irradiated P25TiO₂NPs. Disruption of the superficial skin layer was observed in all animals treated with no functionalized nanoparticles, under irradiation. This data expands the findings by the group of Professors Fubini and Fenoglio, who showed that P25TiO₂NPs could impact the lipid structure at the top few microns of the stratum corneum [55]. Control skin under irradiation and without any topic formulation did not show changes in cell structure.