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The determination of sulfate in various matrices is a critical task for environmental monitoring, industrial process control, and quality assurance in chemical production. When present in high concentrations, sulfates can pose health risks and impact the ecosystem. However, the analytical challenge often lies not just in detecting the presence of sulfates but also in accurately quantifying them, especially when they are to be determined as titanium dioxide (TiO2). This article delves into the methodologies used to determine sulfate as TiO2, highlighting the complexities and nuances involved in such an analysis.

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A few non-dietary studies have reported adverse effects in the gastrointestinal tract of laboratory animals given food-grade TiO2. However, these same effects were not seen when the same or higher doses of food-grade TiO2 were administered in the animals' diet. Dietary studies best reflect how humans are exposed to TiO2 from food. Thus, the Food Directorate placed the most emphasis on the results of these studies in the state of the science report.

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