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A 2023 study published in the journal Particle and Fibre Toxicology set out to examine the impact of titanium dioxide nanoparticles in mice “on the course and prognosis of ulcerative colitis,” by creating an ulcerative colitis disease model. Researchers found that the titanium dioxide nanoparticles significantly increased the severity of colitis. They also “decreased the body weight, increased the disease activity index and colonic mucosa damage index scores, shortened the colonic length, increased the inflammatory infiltration in the colon.” Researchers concluded: “Oral intake of TiO2 nanoparticles could affect the course of acute colitis in exacerbating the development of ulcerative colitis, prolonging the ulcerative colitis course and inhibiting ulcerative colitis recovery.”

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However, China's ascendancy in the titanium dioxide market has also raised environmental concerns. The production process involves significant energy consumption and generates carbon dioxide emissions. With the CAS number 13463-67-7, titanium dioxide production contributes to global greenhouse gas emissions, posing a challenge for sustainable development With the CAS number 13463-67-7, titanium dioxide production contributes to global greenhouse gas emissions, posing a challenge for sustainable development With the CAS number 13463-67-7, titanium dioxide production contributes to global greenhouse gas emissions, posing a challenge for sustainable development With the CAS number 13463-67-7, titanium dioxide production contributes to global greenhouse gas emissions, posing a challenge for sustainable developmentchina dioxide titanium cas 13463-67-7.

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In 2021, the European Food Safety Authority concluded that titanium dioxide is no longer safe in foods due to the same concerns over nanoparticles. As a result, titanium dioxide is now banned as a food additive in the EU. Although studies have shown that the absorption of ingested titanium dioxide is low, evidence suggests that titanium dioxide nanoparticles can accumulate in the body over time. Health Canada deemed it safe in 2022 but noted concerns. Unlike their European counterparts, Canadian officials did not consider studies performed with titanium dioxide nanoparticles alone. 

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