The agency makes this exception for several approved color additives.
ElementisI don't see the scientific evidence in the literature that would cause people any concern, said Kaminski.
In order to achieve the same solids content, the larger filler and the binder should be reduced if necessary.
From studies deemed relevant, the experts found that titanium dioxide as a food additive is poorly absorbed by the gastrointestinal tract of mice and rats, with no adverse effects observed in short-term studies in rodents receiving titanium dioxide in their diets. No observed adverse effect levels (NOAELs) of 15,000 milligrams per kilogram of bodyweight (mg/kg BW) per day and 5,000 mg/kg BW per day—the highest doses tested—were established for mice and rats, respectively.