ld50 titanium dioxide suppliers

One of the main applications of titanium dioxide in paper is in the production of high-quality coated papers. Titanium dioxide is often added to the coating formulations to enhance the whiteness and brightness of the paper surface. This helps to improve the print quality of the paper, as it provides a smooth and even surface for ink to adhere to. The high opacity of titanium dioxide also helps to prevent show-through, making the printed text or images more vibrant and legible.

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For research published in Archives of Toxicology in 2020, scientists fed one group of mice a solution containing titanium dioxide for one month, and compared it to those that did not receive the additive. They found “the richness and evenness of gut microbiota were remarkably decreased and the gut microbial community compositions were significantly changed” in the titanium dioxide group when compared with the control group. The tests also revealed that the titanium dioxide exposure could cause locomotor dysfunction, or mobility issues “by elevating the excitement of enteric neurons, which might spread to the brain via gut-brain communication by vagal pathway.” The researchers concluded: “These findings provide valuable insights into the novel mechanism of TiO2NP-induced neurotoxicity. Understanding the microbiota-gut-brain axis will provide the foundation for potential therapeutic or prevention approaches against TiO2NP-induced gut and brain-related disorders.”

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