Titanium dioxide is a widely used substance in various industries due to its versatility and unique properties. As a result, there are numerous manufacturers of titanium dioxide around the world, catering to the different needs of their customers.

The integrity of surface skin cells was evaluated with and without solar simulated irradiation. The integrity of the stratum corneum was significantly lower in individuals treated with P25TiO₂NPs under the light in comparison to the ones that received the functionalized nanoparticles. Cell membrane suffering is evident (Fig. 9), and it is in accordance with the ROS levels and macromolecule oxidation found in vitro for the irradiated P25TiO₂NPs. Disruption of the superficial skin layer was observed in all animals treated with no functionalized nanoparticles, under irradiation. This data expands the findings by the group of Professors Fubini and Fenoglio, who showed that P25TiO₂NPs could impact the lipid structure at the top few microns of the stratum corneum [55]. Control skin under irradiation and without any topic formulation did not show changes in cell structure.

Anatase titanium dioxide (TiO2) is a key inorganic compound renowned for its exceptional photocatalytic properties, stability, and versatility in various applications. Among the various crystalline forms of titanium dioxide, anatase is particularly favored in industries ranging from paints and coatings to cosmetics and solar cells. The rise of anatase titanium dioxide manufacturers is a testament to the compound’s increasing importance in modern technology and environmental applications.

Lithopone is a white pigment (PW5) co-precipitated from solutions of zinc and barium salts according to the following reaction: 

French researchers studied how and where E171 nanoparticles enter the bloodstream, first studying the route through pigs and then in vitro with human buccal cells, for a 2023 study published in the journal Nanotoxicology. The research showed that the nanoparticles absorbed quickly through the mouth and then into the bloodstream, before damaging DNA and hindering cell regeneration.