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Nano-sized TiO2 generally shows low or no acute toxicity in both invertebrates and vertebrates. However, exposure of Daphnia magna to 20 ppm TiO2 for 8 consecutive days was found to cause 40 % mortality. Zhu et al. showed minimal toxicity to D. magna after 48 h exposure, while upon chronic exposure for 21 days, D. magna suffered severe growth retardation and mortality. A significant amount of nano-sized TiO2 was found also accumulated in the body of the animals. Similar findings with coated nano-sized TiO2 (T-Lite™ SF, T-Lite™ SF-S and T-Lite™ MAX; BASF SE) were reported by Wiench et al. Biochemical measurements showed that exposure to TiO2 NPs induces significant concentration-dependent antioxidant enzyme activities in D. magna. Lee et al. showed that 7 and 20 nm-sized TiO2 induced no genotoxic effect in D. magna and in the larva of the aquatic midge Chironomus riparius.

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In addition to its UV protection properties, P25 TiO2 also offers high photocatalytic activity. When exposed to sunlight, it can break down organic compounds and pollutants, making it an effective agent for environmental remediation. This property makes P25 TiO2 a valuable addition to paints and coatings, as it can help reduce the amount of volatile organic compounds (VOCs) released into the atmosphere, thereby contributing to air quality improvement.

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